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KMID : 0385020030190040271
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Korean Journal of Laboratory Animal Science
2003 Volume.19 No. 4 p.271 ~ p.275
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Transplantation of Olfactory Bulb Promote Locomotor Recovery in Dogs with Spinal Cord Hemisection
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Park Min-Soo
Lee Joo-Myoung
Sim Ki-Bum
Shin Tae-Kyun
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Abstract
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Olfactory bulb fragments were transplanted into hemisected spinal cords of dogs to determine the effect of transplants on locomotor recovery after spinal injury. Dogs were rendered hemiparaplegic via hemisection of the spinal cord at the T9/10 level and received an autologous transplant of a piece of olfactory bulb tissue. After surgery, locomotor recovery was observed and graded on a scale of 0 to 5, weekly for 4 weeks. Dogs that received olfactory bulb transplants significantly have shown progressive locomotor recovery at three weeks post-transplantation from complete paralysis to partial recovery of hindlimb gait (p<0.05). At four weeks post-transplantation, some cells from the transplanted tissues were found within the spinal parenchyma upon histopathologic examination. These findings suggest that autologous transplantation of olfactory bulb may contribute to the repair of spinal cord injuries and recovery of locomotion in dogs.
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KEYWORD
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Spinal cord injury, Olfactory bulb, Transplantation
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